Clinical
Case Report

Quantifying Muscle Compressibility as a New Decision Support

November 29, 2025
Quantifying Muscle Compressibility as a New Decision Support

When pressure readings and clinical signs diverge.

Objective

Introduction

Conventional diagnostic criteria for compartment syndrome have shown limited reliability in capturing evolving tissue compromise. Recent investigations have shown that static pressure thresholds and one-time measurements provide limited diagnostic value, with substantial variability across techniques and poor correlation to actual tissue ischemia. Pressure alone has been shown to be an unreliable surrogate for microvascular compromise, while the classic “P” signs offer low predictive accuracy. These findings reveal a gap between static pressure data and the dynamic state of tissue health [1,2].

Solution

Case Presentation

• A 40-year-old female sustained a displaced tibial plateau fracture (fig.1) with marked soft-tissue swelling, conferring ~50% ACS risk.

• Temporary stabilization was achieved using an external fixator.

• Continuous invasive Intracompartmental Pressure (ICP) monitoring was initiated.

Figure 1.Comparative radiographic views of the proximal tibia
Figure. 2. Intracompartmental pressure and muscle compressibility trends over time.


Result

ICP Trend

Initial pressure 30 mmHg, rising to 45 mmHg within 2 hours, remaining elevated for ~20 hours.

Clinical Status

ICP values were not correlated with the clinical examination. The patient showed no progressive pain, neurological deficit, or tense compartment.

Quantis ST Measurements

During this period, non invasive soft-tissue compressibility measurements were performed using Compremium Quantis® ST. Compressibility values dropped from 16.3% to 5.2% within 6 hours, followed by a recovery to the baseline of 16.3% after ~2 hours.

Outcome and conclusion

ICP remained high; treating doctors could not correlate the values with clinical findings.

Compressibility measurements provided a more accurate reflection of clinical assessment and patient outcomes.

Based on these findings, no prophylactic fasciotomy was performed.

The patient remained stable and achieved full functional recovery without complications.

This case was presented at OTA 2025 by Andrew H. Schmidt, MD Chief Orthopedic Surgery Hennepin Healthcare Minneapolis, MN, USA