Unlocking Diagnostic Breakthroughs in Compressibility and Occlusion Pressure

Compressibility

Compressibility quantifies the degree to which tissue changes in response to pressure induced injuries.

Relative Compressibility: 15.4%

Normal
compressibility

Reduced
compressibility

Compressibility
ratio

Uncompressed state

Compressed state

A simple, yet powerful concept

Healthy compartments are more compressible than compartments at risk.

Compressibility versus pressure

Compressibility and pressure are in negative linear correlation.

Pressure

Vascular Occlusion Pressure

Occlusion pressure is the method of assessing pressure at the point of occlusion for any vessel of interest.

Areas of research

Our potential to transform traditional diagnosis

Vascular

Compartment

Portal

Intra-muscular

Skin

Intra-abdominal

Intra-ocular

Intra-cranial

Pressure is a crucial diagnostic parameter

By harnessing the power of pressure,
Compremium can enable the diagnosis
of acute and chronic conditions.

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Neurology

Intracranial pressure

Increased intracranial pressure indicates a rise of pressure inside the skull that can result from and cause brain injury

OpHthaLmology

Intraocular hypertension

Intraocular hypertension indicates a rise of pressure inside the eyes that can cause blindness from glaucoma or other eye disorders

Rheumatology

Intramuscular pressure

Recent studies indicate that intramuscular pressure is correlated to various conditions such as fibromyalgia and myofascial pain syndrome

Vascular

Vascular pressure

Vascular pressure which includes both arterial and venous pressure can be an important parameter in diagnosing various conditions related to venous insufficiency and peripheral arterial conditions

Hepatology

Portal pressure

Portal venous hypertension is directly linked to various liver conditions like liver fibrosis and liver cirrhosis

Gastroenterolgy

Intra-abdominal pressure

Measuring intra-abdominal pressure in critically ill patients

Dermatology

Intrafascial membrane fluid pressure

Scleroderma and skin edema leading to fibrosis

Neuromuscular

Intramuscular pressure

Intramuscular pressure is associated with various conditions such as muscular dystrophy, sarcopenia and cachexia

Orthopedics

Compartment pressure

Acute and chronic compartment syndrome is directly related to the rise in intramuscluar pressure

Podiatry

Tissue pressure

Various peripheral conditions such as neuropathy can be attributed to interstitial fluid pressure

The Science

Compressibility is a simple yet immensely powerful tool that we are using to achieve more reliable diagnostics.
‍
In clinical trials we’ve proven to be highly accurate in diagnosing certain musculoskeletal conditions.

sensitivity

specificity

Disclaimer
The CPMX1 has received FDA clearance for the following indication for use: “The Compartmental Compressibility Monitoring System (CPM#1)
is intended for real-time and intermittent monitoring of relative compartment compressibility.
The relative compartment compressibility (CP Value) is not meant for trend analysis.”

K223509 510(k) Summary

Clinical Studies

‍Healthcare professionals can apply to become an investigator and obtain the device for investigational use
by sending a request to info@compremium.ch

Partners

Great work is never done alone.

Compremium Corp. Receives FDA clearance for the CPMX1 System

Publications

Non-invasive assessment of muscle compartment elasticity by pressure related ultrasound in pediatric trauma: A prospective clinical study in twenty-five cases of forearm shaft fractures

Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt

Ultrasound-guided venous pressure measurement

Tibial anterior compartment compressibility in healthy subject, measured using compression sonography

Non-invasive and reliable assessment of compartment elasticity by pressure related ultrasound; An in-vitro study

Non-Invasive Diagnostics in Acute Compartment Syndrome

A dual-sensor ultrasound based method for detecting elevated muscle compartment pressures: A prospective clinical pilot study

Non-invasive measurement of muscle compartment elasticity in lower limbs to determine acute compartment syndrome: Clinical results with pressure related ultrasound

Venous and Arterial Responses to Partial Gravity

Assessment of Jugular Venous Blood Flow Stasis and Thrombosis During Spaceflight

Use of standard musculoskeletal ultrasound to determine the need for fasciotomy in an elevated muscle compartment pressure cadaver leg model

A Novel Non-invasive Method for the Detection of Elevated Intracompartmental Pressures of the Leg

Noninvasive Assessment of Intra-Abdominal Pressure Using Ultrasound-Guided Tonometry: A Proof-of-Concept Study

Compression sonography for non-invasive measurement of lower leg compartment pressure in an animal model

Internal jugular pressure increases during parabolic flight

Measurement of compartment elasticity using pressure related ultrasound: a method to identify patients with potential compartment syndrome

Assessment of elevated compartment pressures by pressure-related ultrasound: a cadaveric model

Pilot Study to Evaluate a Novel Non-Invasive Technology to Measure Peripheral Venous Pressure

Automatic Measurement of Venous Pressure Using B-Mode Ultrasound

Non-invasive pressure measurement of the great saphenous vein in healthy controls and patients with venous insufficiency

Prospective Comparison of Noninvasive, Bedside Ultrasound Methods for Assessing Central Venous Pressure

Central venous pressure and impaired renal function in patients with acute heart failure

Central Venous Pressure at Emergency Room Presentation Predicts Cardiac Rehospitalization in Patients with Acute Decompensated Heart Failure

Non-invasive central venous pressure measurement by compression ultrasound - a step into real life

Noninvasive Central Venous Pressure Measurement by controlled Compression Sonography at the Forearm

Estimation of Central Venous Pressure by Ultrasound